Before she was a year old, Barrymore had already appeared in her first commercial, and at the ripe old age of 4 snagged her first movie role in Alerted States.
Her most famous role come a few years later as Gertie in tv episodes E.T. The Extra-Terrestrial, with more star assignments quickly following in Irreconcilable Differences and in the film version of Stephen King's Firestarter.
Suddenly a roller coaster career in films was saw in the young famous celebirty.
At 21, Barrymore's career began again in an upward direction with critical raves for “nice girl” roles in Woody Allen's Everyone Says I Love You, followed a few years later with a gentle, endearing performance in The Wedding Singer and finally as a lovelorn young innocent in Never Been Kissed.
Regaining her reputation as a solidly bankable star, Barrymore next appeared in the hugely popular Charlie's Angels with Cameron Diaz, and became the real-life producer of the cult classic, Donnie Darko starring Jake Gyllenhaal.
In 2005, the actress won for "Favorite On-Screen Chemistry" alongside Adam Sandler at the People's Choice Awards for her performance in Fifty First Dates.
Barrymore's latest silver screen appearances have included Fever Pitch, opposite comedian Jimmy Fallon, Music and Lyrics co-starring Hugh Grant, and Lucky You with Eric Bana.
The actress recent projects turns producer and stars in the summer comedy He's Just Not Into You, co-starring Jennifer Aniston and Scarlett Johansson, scheduled to open in August.